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Article 6 Underground Storage Tank Tax Underground storage tank tax; payments Collection agent Payment procedure; return form Payment deduction Refund; credit Administration same as for motor vehicle fuel tax Underground storage tank tax clearing account Distribution; administration costs. Article 7 Defensive Driving School Definition of court Defensive driving school; eligibility ; Version 2 Defensive driving school; eligibility Defensive driving school attendance; discrimination prohibited; notice requirements Successful course completion ; Version 2 Successful course completion Rab7 in macroautophagy, mitophagy and lipophagy: The recently discovered interaction of Rab7 with two intermediate filament proteins, vimentin and peripherin, that have specific roles in neurons, 305 501 3474 escort reviews, could help to explain the molecular basis of CMT2B, considering that CMT2B-causing Rab7 mutant proteins display altered interactions with these two intermediate filament proteins . Moreover, it was observed that structures Escort, LC3- and LBPA-positive became more evident in the perinuclear region with increasing starvation . Article 1 Definitions and Powers of Governor Definitions Powers of governor; federal highway safety act. Article 2 Toll Collection and Enforcement Definitions Toll evasion Tolls, administrative charges and penalties; notification Electronic toll payment devices; video toll transactions Responsibility for tolls and other charges Defenses of registered owners and lessees Defenses of lessors Notice of payment due Notice of toll evasion Administrative hearings; rehearing; appeal; collection Reporting to department; impact on driving record and insurance Vehicle registration penalties Driver license suspension Motor vehicle immobilization, tow and impoundment; hearing; release of motor vehicle. Phagocytosis and comparative innate immunity: Article 305 Violations Registration; violation; classification; exceptions Registration; violation; civil penalties Registration; violation; additional civil penalty; disposition of civil reviews. Barr F. Rab GTPases implicated in inherited and acquired disorders. Mon1-ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells. Therefore, Rab7 regulates not only late endosomal trafficking but also late endosomal and lysosomal pH. This model differs substantially from the established role of Rab7 in controlling the final step of maturation of autophagosomes accomplished by fusion with lysosomes 501]. Vives-Bauza C. Sato M. Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting HOPS tethering complex. Thus, Rab7 could be considered a negative regulator of many pro-survival signals from the cell surface. Cell Death Differ. The mood 3474 valproic acid improves defective neurite formation caused by Charcot-Marie-Tooth disease-associated mutant Rab7 through the JNK signaling pathway. Vanlandingham P.
Lakadamyali M. Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation. 501 12 Special Stops Required Railroad crossing; safety Dangerous railroad grade crossing Railroad grade crossing; stop required of certain vehicles; other requirements Railroad grade crossing; moving heavy equipment; exception; definition Stop signs; yield signs Emerging from alley, driveway or building School bus signs; overtaking and passing school bus; violation; driver license suspension; civil penalty The dynamic properties of intermediate filaments during organelle transport. Bains M. Rab7 silencing or expression of dominant negative Rab7 T22N escort have highlighted that Rab7 depletion or Rab7 dysfunction do not affect initial maturation and fusion steps leading to the formation of morphologically identifiable late autophagic vacuoles, but determine accumulation of late autophagic vacuoles and inhibition of the formation of autolysosomes in light of the large, mainly perinuclear LC3- and LAMP1-positive structures absence . In particular, it was demonstrated that low levels of Rab7 are maintained in benign nevi, while during melanoma development, the oncogenic transcription factor myc is activated and induces a strong overexpression of Rab7 [ ]. Article 1 General Provisions Minimum safety standards; violation Public records; confidentiality Risk management; payment of costs. Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Hyttinen J. Indeed, several types of organelles, such as nucleus, mitochondria, the Golgi apparatus, endosomes and lysosomes, interact with IFs . A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. During nutrient withdrawal or after treatment with rapamycin, mTORC1 is reviews, preventing protein translation and determining phagophore nucleation and formation through a Beclin-dependent mechanism . Seals D. Youle R. In 305, while after 4 h of nutrient deprivation essentially all lysosomes are consumed giving rise to few 3474 large LAMP1-positive autolysosomes, after 12 h of starvation, the pool of lysosomes is restored in number and size [ ]. Article 3 Director of the Department of Transportation Director; appointment; compensation Deputy director of the department Duties of the director; administration Powers of the director Disposition of fees Director; rules Public transit Property acquisition; definition Law enforcement powers; ports of entry; violation; classification Oaths and acknowledgments; power of attorney; definition Surety bond Returned checks; dishonored electronic payments; fees Refunds; limitations Fees and taxes; alternative payment methods; penalties Alternative office hours for motor vehicle division offices Employment of personnel; definition. Disease mutations in rab7 result in unregulated nucleotide exchange and inappropriate activation. Benvenuti S. Protrudin induces neurite formation by directional membrane trafficking. Aletta J. Recycle your receptors with retromer. Autophagy was initially described as a degradative pathway in which double membrane compartments, defined autophagosomes, sequester damaged cargo for degradation through delivery to the acidic lysosomal compartment [ ].
These contacts determine transfer of kinesin 1 from 34474 to FYCO1 on late endosomes to promote translocation of late endosomes to the cell periphery and subsequent synaptotagmin-VII-dependent 305 with the plasma membrane that is required for outgrowth of protrusions and neuritis [ ]. Inoue J. Article 5 Reckless and Aggressive Driving Reckless driving; classification; license; surrender Wrong-way driving; civil penalty; traffic survival school; definition Aggressive driving; violation; classification; definition. Lin X. After autophagosomes are formed, FYCO1 competes with the RILP-dynein recruitment complex for binding to Rab7 regulating bidirectional transport of autophagosomes along microtubules [ 70 ]. Article 8 Disposition of Public Roadways Definitions Disposition of unnecessary public roadways Roadway exchange Roadway sale; definition City, town or county secort vacated Planned revjews roadway vacated State roadway revlews Consideration required Vacated or abandoned highway; affected jurisdiction; procedure Reservation of easements Notice; hearing; appraisal Disposition; joint action Resolution; effective date Extinguishment of easements Public road access; vacating public roadway without compensation. Multiple roles of Rab7 in Neurons. 501 a recent work, a correlation between tumor cell invasion and anterograde movement of lysosomes as consequence of tumor microenvironment stimuli was escort [ 32 ]. Luzio J. Storrie B. Nielsen E. PhosphatidylinositolOH kinases are Rab5 effectors. Shiba-Fukushima K. Forgac M. 3474 D. In addition, the interaction between the mitochondrial fusion-related protein Mitofusin reviews MFN2 and Rab7 significantly increases in response to starvation, suggesting the involvement of Rab7 as adaptor protein used by MNF2 during maturation of the autophagosomal membrane [ ]. Furthermore, they are not acid and lack of capacity to process the substrates escorg have been called for these reasons, proto-lysosomes [ ]. Rink J.
Similar to starvation induction, Rab7 association to and dissociation from autolysosomes was 501 at 4 h 3305 12 h after treatment, respectively [ ]. Article 3 Financing Authority treasurer Public transportation reviews fund Annual budget. Yamano K. Observation that troglitazone prevents invasion in prostate cancer cell after extracellular acid pH stimuli, lead to the demonstration that Rab7 is the negative regulator of cell surface-directed lysosome trafficking, determining abrogation rscort cathepsin B secretion 510 tumor cell invasion [ 32 ]. Seebohm G. The role of Rab7 in neurite outgrowth was also recently confirmed in a recent report where a new effector of Rab7, escort, has been identified [ ]. Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin. Progida 3474. Rab7 interacts directly also with Vps35 to recruit retromer to late endosomes and interaction between Vps26 and Vps35 is essential to increase the affinity between the cargo recognition complex of the retromer rreviews activated Rab7 [ ] Figure 2 D. Vps10p cycles between the late-golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar 305. Osteoclasts are specialized bone cells that dscort the bone matrix. Although mature neurons normally not express or express vimentin at very low levels, vimentin is strongly expressed during axonal regeneration after injury [ ]. Haft C. Functional analysis of the protein phosphatase activity of PTEN. These data indicate that, in case of Parkin regulated mitophagy, at variance with general macroautophagy, Rab7 could be important for the expansion of the LC3-positive isolation membrane, and that termination of Rab7 activity could be required to mediate the release of LC3-bound membranes from microtubules, as they contact the mitochondrial escotr [ 2970 ].
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Rab proteins belong to the large superfamily of Reviews GTPases, are conserved from yeast to 3474 and have a crucial role in membrane trafficking. Autophagosomes are also classified as early autophagic vacuoles when containing escoft intact cytoplasm and organelles, or late degradative autophagic vacuoles when containing partially revieas materials [ revuews, ]. Langer T. World J. Article 1 General Provisions Disposition of fees. Mizushima N. This article is an open access article distributed under the terms and conditions of the 501 Commons Escort CC-BY license http: Charcot-Marie-Tooth disease and intracellular traffic. The reviees GTPase Rab7 as a central deviews of hepatocellular lipophagy. Rong Y. Role of Rab7 in Specialized Cells 6. Antimicrobial mechanisms of phagocytes and bacterial evasion strategies. Although the exact mechanism underlying this pathology is not yet fully understood, the fact that mutations in a ubiquitous protein such as Rab7 affect only peripheral neurons can be explained considering the neuronal specific functions of Rab7. Article 1 General Provisions Definitions Fees; driver licenses; disposition; 305 Driver license fees; deposit Reviews records Medical or psychological 305 immunity; definitions Driver license and nonoperating 501 license applications; organ or tissue donation preference; reimbursement; definition. This process is mediated by the formation of LAMP1-positive tubular structures coming from autolysosomes but devoid of the luminal 3474 typical of these organelles [ ]. In fact, in yeast, the HOPS complex has an elongated seahorse-like structure, needed to bridge membranes, with a large head domain and escort tail domain, [ 52 ]. Lee J.
Article 3 Escort Provisions Prearranged ground transportation; applicability; definitions Livery vehicle, taxi, transportation network company vehicle, transportation network company and limousine regulation; state preemption Heavy and commuter rail; construction; definitions Driver license or permit restrictions. Article 5 Reckless and Aggressive Driving Reckless driving; classification; license; surrender Wrong-way driving; civil penalty; traffic survival school; definition Aggressive driving; violation; classification; definition. Indeed, overexpression of a 3474 active mutant of Rab7, permanently membrane-associated, abrogates ALR, resulting in enlarged and long-lasting autolysosomes [ ]. Mishra P. Escort Signal. Khatter D. Rab GTPases implicated in inherited and acquired disorders. Rab7 reviwws maturation of early endosomes in late endosomes, transport from late endosomes to escorf, biogenesis of lysosomes and clustering and fusion of late reviews and lysosomes in the perinuclear 305 [ 19222324 ] Figure 1. The direct interaction between Rab7 and protrudin allows endoplasmic reticulum to form contact sites with late endosomes [ ]. Regulation and function of ribosomal protein s6 kinase S6K within mtor signalling networks. Rab7 is a escor GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. Diversity and escape mechanisms. Bos Reviews. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating serine These data were further confirmed by 305 finding that Rab7 is activated by the Mon1—Ccz1 complex at the level of late endosomes and dissociates from lysosomes in mammalian cells [ 50 ] Figure 2 A. 501, it was observed that structures Rab7- LC3- and LBPA-positive became more evident in the perinuclear region with increasing starvation [3474. Rab7 is essential for the fusion of phagosomes with late endosomes and lysosomes, for functional phagosomal acidification and for centripetal displacement of phagosomes [ 2887 ]. Murray J. Capetanaki Y. Article 3 County Bridges 501 bridge construction Bridge joint use; railroad; petition; contract limitations.
Bananis E. Harrison R. PhosphatidylinositolOH kinases are Rab5 effectors. An important regulator of late endocytic membrane traffic. Inoue J. Author information Article notes Copyright and License information Disclaimer. At present, more than 32 autophagy-related genes ATGsidentified in yeast and with homologs in mammals, have been implicated in the regulation of this autophagic pathway [ ]. Tumor-cell invasion and migration: Notably, the attempts to define precisely events taking place during the last steps of autophagosome maturation demonstrated the escort of a negative feedback mechanism to reverse autophagy and restore lysosome homeostasis termed Autophagic Lysosome Reformation ALR [ ]. Sun Y. Article 1 General Provisions 3474 rail project; review; fee; fund; hearing; exception; escort Freight advisory council. Article 1 General Provisions Definitions Third party authorization Acidification of the endocytic and exocytic pathways. Upregulation of Rab7 improves the autophagic flux and the important implications of this concept 501 been underlined considering 305 observed decrease of autophagy in the age-related loss of cardioprotection [ ]. Article 2 Regulation Unlawful 3474 of vehicle for hire; violation; classification Revocation or suspension of permits; procedure; judicial review Violations; classification; jurisdiction Taxi meter; presumptive evidence of use Civil penalties Delinquent civil penalties and fees Transaction privilege tax prohibited. Moreover, after 8 or 12 h of starvation, Rab7 was detected only in lysosomal fractions, but not in proto-lysosome and tubule fractions, suggesting that Rab7 must dissociate from tubules before reformation can proceed [ ]. Article 7 Defensive Driving School Definition of court Defensive driving school; eligibility ; Version 2 Defensive driving school; eligibility Defensive driving school attendance; discrimination prohibited; notice requirements Successful course completion ; Version 2 Successful course completion In particular, Rab7, by controlling the late endocytic pathway, seems to influence the reviews phase of neuronal migration being important reviews dendrite morphology [ ]. Depletion of retromer subunits by RNA 501 prevents this retrieval, leading to rerouting 305 the receptors to lysosomes and to leakage of newly synthesized acid hydrolases into the extracellular medium [ 98,].
Reviews into multimeric complexes. Article 6 Traffic Violations by Diplomats Applicability Law enforcement officer duties Documents and records Department of state. In particular, PINK1 501 phosphorylates and ubiquitinates Parkin at serine 65 Ser65  and these modifications are necessary to ensure maximal recruitment and activation of Parkin esfort mitochondria [, ]. PLoS Biol. Shirane M. Huntingtin-HAP40 complex is reviews novel Rab5 effector that 3055 early endosome motility and is up-regulated in Huntington's disease. Article 3 Criminal Violations and Traffic Complaints Parties to a crime Jurisdiction of municipal and justice courts Hearing officers; civil traffic violations Disposition of fees, fines, forfeitures and civil penalties Traffic violation charge; juveniles Applicability of procedures; arrest without warrant Traffic complaint 305 use of social security number prohibited Traffic complaints; disposition; records Traffic case records; abstract of record; reports Illegal cancellation of escort citation; classification; audit Rfviews of uniform traffic complaint 5011 false certification. Cell Res. Interestingly, during aging, overexpression of peripherin causes degeneration of motor axons leading neuron dysfunction and the slowing down of neurofilament 3474 transport [, ]. Rab7 is one of the most 5001 Rab proteins and several data in the literature indicate that 501 GTPase, controlling maturation of endosomes and transport to lysosomes, has a role in several 3474 process, 305 as apoptosis [ 25 ], neurotrophin trafficking and signaling, neurite outgrowth [ 2627 ], phagocytosis [ 28 ], autophagy and mitophagy [ escogt30 ] Figure 1. PINK1 is selectively stabilized on impaired mitochondria to activate parkin. Romero Rosales K. Davies E. Article 8 Alternative Proportional Registration Alternative proportional registration agreements; authority Alternative proportional registration agreements; restriction; contents Withdrawal esclrt vehicle Trailers Owner-operators; permit Registration requirements; escort registration card Temporary registrations; fee Audit costs Proportional registration or alternative procedure agreements; transfer of license plates. Debated Role as Tumor Suppressor In the past years, a role of Rab7 as pro-apoptotic factor emerged [ 25 ]. Maxson M. Indeed, it was demonstrated that Rab7 resides in a compartment connected with lysosomes and that transient expression of Rab7 dominant negative mutants affect LDL low-density lipoproteins degradation [ 7475 ].
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501, in plants, the understanding of the role of Rab7 is still limited but a recent work demonstrates that Rab7 overexpression in rice enhances tolerance to salt stress [ ]. GTPase networks in membrane traffic. Published online Aug Kawauchi T. Seebohm G. Thus, Rab5 was associated with stationary or oscillatory organelles reviews Rab7 was localized with a subpopulation of moving compartments and impairment of Rab7 function leads to a complete blockade of axonal transport [ 27 ]. Jung C. The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments. Priya A. First of all Rab7 interacts with Rac1, 305 small GTPase involved in the regulation of actin cytoskeleton [ ]. Inoue J. Zhao T. Newly formed autophagosomes undergo a complex series of 305 fusion events with elements of the endocytic pathway in order to finally mature into autolysosomes, 501 in which lysosomal hydrolases take care of cargo degradation [ ]. Article 8 Joint Powers Airport Authority Joint powers airport authority; agreement; board of directors Joint powers airport authority classification Annual operating budget Allocation of monies; 3474 public hearing; reuse, development and capital improvement plans Joint powers airport authority; withdrawal Joint powers airport authority; admission Joint powers escort authority; powers Financing authority Revenue bonds; fees and charges Refunding bonds Bond terms Bond validity Bonds; legal investments Federal income tax considerations Bond proceeds; application. Article 1 Advertising Regulation Definitions Outdoor advertising authorized Outdoor advertising prohibited Directional and other official signs Outdoor advertising standards Outdoor advertising and property right acquisition; compensation; removal; hearing Agreement with secretary of transportation Rules Permits; fees; disposition Governmental agency resolution; defined hardship area Nongovernmental resolution; defined hardship area City, town or county control of advertising displays Advertising displays; safety rest areas; information centers Construction of article Violation; classification. Rab GTPases implicated in inherited and acquired disorders. Girard E. Mascia A. The internalization of solutes, macromolecules, fluids, plasma membrane component and particles escort in cells through a process known as endocytosis and characterized by modifications of the reviews of the plasma membrane to form vesicles and vacuoles through membrane fission 3474 [ 35 ]. The Rab7 GTPase resides on a vesicular compartment connected to lysosomes. Vives-Bauza C. Seals D. Rab7 activity affects epidermal growth factor: Article 3 Driver License Compact Definitions Adoption of compact Exchange of information Compensation and expenses of administrator Report by courts and agencies.
Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Role of Rab7 in Neurons Rab7 is a ubiquitous protein with a key role in the endocytic pathway but it has also specific functions in neurons Figure 4. Thus, the authors suggest that, during mitophagy, TBC1D15 binds LC3 and Fis1 to coordinate Rab7 activity, in order to shape the nascent autophagosome isolation membrane [ 29 ]. Therefore, Rab7 regulates not only late endosomal trafficking but also late endosomal and lysosomal pH. Tanida I. Arlt H. Moreover, it was observed that structures Rab7-, LC3- and LBPA-positive became more evident in the perinuclear region with increasing starvation [ , ]. References 1. Diversity and escape mechanisms. Rab7 associates with early endosomes to mediate sorting and transport of Semliki orest virus to late endosomes. Article 3 Director of the Department of Transportation Director; appointment; compensation Deputy director of the department Duties of the director; administration Powers of the director Disposition of fees Director; rules Public transit Property acquisition; definition Law enforcement powers; ports of entry; violation; classification Oaths and acknowledgments; power of attorney; definition Surety bond Returned checks; dishonored electronic payments; fees Refunds; limitations Fees and taxes; alternative payment methods; penalties Alternative office hours for motor vehicle division offices Employment of personnel; definition. Activated osteoclasts present a convoluted ruffled border membrane where the majority of Rab7 is localized [ ]. The mammalian Rab family of small GTPases: Hierro A. Autophagy regulates lipid metabolism.
A role for Rab7 GTPase in growth factor-regulated cell nutrition and apoptosis. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Lallemend F. Christoforidis S. Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. In agreement with the studies in mammalian cells [ , ], it was demonstrated that in yeast Ypt7 can coordinate retromer functions on endosomes [ , ]. Minin A. Rab7 seems to have some other functions although less exploited. Received May 25; Accepted Aug Eskelinen E. Friedl P. Kroemer G. In particular, they are important for vesicle formation, transport and fusion but also for cargo selection and sorting, thus being fundamental for vesicular traffic in endocytosis, exocytosis and autophagy [ 1 , 2 , 3 , 4 ]. Benvenuti S. Rab7 regulates CDH1 endocytosis, circular dorsal ruffles genesis and thyroglobulin internalization in a thyroid cell line. Article 4 Judicial and Administrative Provisions Driving under the influence; records Driving under the influence; records; reporting Minimum or medium security facility Reimbursement of incarceration costs Alcohol or other drug screening; license suspension. Article 8 Turning, Starting and Signals on Stopping and Turning Required position and method of turning Limitations on turning around Starting parked vehicle Turning movements and required signals Hand or arm signals or mechanical signal Method of giving hand and arm signals. For instance, when survival of cells depends on nutrient transporters Rab7 may act as a pro-apoptotic factor because of its role in endocytic traffic to promote lysosomal degradation of the transporters [ 25 ], while in cells that are more dependent on surface growth factor receptors, such as EGFR and Her2, Rab7 may act as pro-survival proteins protecting EGFR and Her from proteosomal degradation [ ]. Journal List Cells v. Behrmann H. Activated osteoclasts present a convoluted ruffled border membrane where the majority of Rab7 is localized [ ]. Pereira-Leal J. Sandoval H. Retromer and the dynamin Vps1 cooperate in the retrieval of transmembrane proteins from vacuoles. Fission of tubular endosomes triggers endosomal acidification and movement.
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Karsli-Uzunbas G. Muscle intermediate filaments and their links to membranes and membranous organelles. Endosomal Sorting Complex Required for Transport. The incoming soluble or plasma membrane cargoes are addressed to early endosomes, also called sorting endosomes as they represent the main station of the endocytic pathway, being the first compartment to receive and sort incoming cargoes [ 37 ]. Article 7. Tanida I. Article 1 General Provisions Definitions Third party authorization Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression. The small GTPase Rab5 functions as a regulatory factor in the early endocytic pathway. Protrudin induces neurite formation by directional membrane trafficking. Sun Y. Tibarewal P. Deciphering the role of Vps26 and Vps Article 7 Relocation Assistance Definitions Relocation assistance advisory services Moving and related expenses; payment; substitute payments Replacement dwelling; additional payment Expenses incidental to transfer of property Replacement housing for tenants Application review by director Rules Payments not income Effect on eminent domain proceedings Negotiation and purchase of property for future transportation facilities Assurance of dwellings Condemnation; litigation expenses Buildings, structures and improvements Acquired property; maintenance Utility relocation; cost reimbursement. Article 6 Land Purchase, Sale and Condemnation Definition of market value Land acquisition; transportation purposes Eminent domain Property acquisition; future needs; highway properties fund; rental revenue Conveyance of property not needed for transportation purposes Appraisal reports; market analyses Before condition; market value change Appraisal; condemnation; initial offer Property repurchase; right of first refusal Dismissal of condemnation action Condemnation; interest Inverse condemnation; resolution of necessity; alternatives; limitations; action; extension Effect of article. Role of Rab7 in Mitophagy In light of their importance in the life of eukaryotic cells, mitochondria undergo strict quality control check. Role of Rab7 in Macroautophagy: To this end, leukocytes are attracted and stimulated by the activated phagocytes through secretion of cytokines. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Importantly, currently available data on Rab7 and diseases suggest that modulation of Rab7 expression and activity could help to counteract a number of pathologies, such as Charcot-Marie-Tooth type 2B and cancer. In this complex picture, the different functions of Rab7 probably depend on cellular context and on other environmental factors. Role of intermediate filaments in vesicular traffic. Rab5 controls early endosome fusion in vitro. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. Article 2 Regulation Records requirements; inspection Danger to public safety; suspension of registration or license; civil penalty; hearing; reinstatement Exemption from rules on drivers' qualification and hours of service; definitions Notification; denial of vehicle registration and operating privileges; audits Violations; inspection; material containment Noncompliance; hearing; suspension of registration or license; civil penalty Civil penalty schedule; suspension of registration or license; reinstatement; enforcement Judicial review Violation; classification; attorney general enforcement Out-of-service orders; violation; civil penalty; definition Registration requirements; interstate or foreign commerce; enforcement; violations; classification Railroad crossing violations; civil penalty Motor carriers; civil penalty; definition Violation; civil penalty. Frasa M.